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KMID : 0355620100360060502
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2010 Volume.36 No. 6 p.502 ~ p.507
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Genetic influence and heritability in mandibular prognathism of Korean families
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Kim Young-Ho
Cho Han-Young
Baek Chae-Hwan
Lee Ah-Young
Kim Gun-Jong
Kim Whi-Young
Suh Young-Ju
Baek Seung-Hak
Hong Jong-Rak
Paeng Jun-Young
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Abstract
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Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families.
Materials and Methods : Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center.
Results:The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2, 84.1 and -2.9, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method) was estimated to be 29.8% (0.298±0.059) in first-degree relatives.
Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion
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KEYWORD
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Mandibular prognathism, Genetic influence, Epidemiologic investigation, Heritability
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